Delphinidin prevents high glucose-induced cell proliferation and collagen synthesis by inhibition of NOX-1 and mitochondrial superoxide in mesangial cells

Delphinidin prevents high glucose-induced cell proliferation and collagen synthesis by inhibition of NOX-1 and mitochondrial superoxide in mesangial cells

This study examined the effect of delphinidin on high glucose-induced cell proliferation and collagen synthesis in mesangial cells. Glucose dose-dependently (5.6–25 mM) increased cell proliferation and collagen I and IV mRNA levels, whereas pretreatment with delphinidin (50 μM) prevented cell prolif...

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Bibliographic Details
Main Authors: Seung Eun Song, Hye Jun Jo, Yong-Woon Kim, Young-Je Cho, Jae-Ryong Kim, So-Young Park
Format: Article
Language:English
Published: Elsevier 2016-04-01
Series:Journal of Pharmacological Sciences
Subjects:
Delphinidin
High glucose
Mesangial cells
NOX-1
Reactive oxygen species
Online Access:http://www.sciencedirect.com/science/article/pii/S1347861316000402

Internet

http://www.sciencedirect.com/science/article/pii/S1347861316000402

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