Systems Biology Strategy Reveals PKC-delta is Key for Sensitizing TRAIL-Resistant Human Fibrosarcoma

Systems Biology Strategy Reveals PKC-delta is Key for Sensitizing TRAIL-Resistant Human Fibrosarcoma

Cancer cells are highly variable and resistant to therapeutic intervention. Recently, the use of the tumor necrosis factor related apoptosis-inducing ligand (TRAIL) induced treatment is gaining momentum, due to TRAIL’s ability to specifically target cancers with limited effect on normal cells. Howev...

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Bibliographic Details
Main Authors: Kentaro eHayashi, Sho eTabata, Vincent ePiras, Masaru eTomita, Kumar eSelvarajoo
Format: Article
Language:English
Published: Frontiers Media S.A. 2015-01-01
Series:Frontiers in Immunology
Subjects:
Apoptosis
Protein Kinase C
Cancer
computational modeling
cell dynamics
Signaling Pathways
Online Access:http://journal.frontiersin.org/Journal/10.3389/fimmu.2014.00659/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fimmu.2014.00659/full

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