Tamoxifen attenuates renal fibrosis in human kidney slices and rats subjected to unilateral ureteral obstruction

Tamoxifen attenuates renal fibrosis in human kidney slices and rats subjected to unilateral ureteral obstruction

Background and Purpose: Renal fibrosis plays an important role in the development and progression of chronic kidney disease (CKD). Clinical studies have shown that CKD progresses differently in males and females, which may be related to circulating levels of sex hormones. In this study, we investiga...

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Bibliographic Details
Main Authors: Stine Julie Tingskov, Michael Schou Jensen, Casper-Emil Tingskov Pedersen, Isabela Bastos Binotti Abreu de Araujo, Henricus A.M. Mutsaers, Rikke Nørregaard
Format: Article
Language:English
Published: Elsevier 2021-01-01
Series:Biomedicine & Pharmacotherapy
Subjects:
Tamoxifen
Renal fibrosis
Unilateral ureteral obstruction
Human precision-cut kidney slices
Online Access:http://www.sciencedirect.com/science/article/pii/S0753332220311951

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http://www.sciencedirect.com/science/article/pii/S0753332220311951

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