FACT and Ubp10 collaborate to modulate H2B deubiquitination and nucleosome dynamics

FACT and Ubp10 collaborate to modulate H2B deubiquitination and nucleosome dynamics

Monoubiquitination of histone H2B (H2B-Ub) plays a role in transcription and DNA replication, and is required for normal localization of the histone chaperone, FACT. In yeast, H2B-Ub is deubiquitinated by Ubp8, a subunit of SAGA, and Ubp10. Although they target the same substrate, loss of Ubp8 and U...

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Bibliographic Details
Main Authors: Melesse Nune, Michael T Morgan, Zaily Connell, Laura McCullough, Muhammad Jbara, Hao Sun, Ashraf Brik, Tim Formosa, Cynthia Wolberger
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2019-01-01
Series:eLife
Subjects:
histone chaperone
ubiquitin
deubiquitinating enzyme
nucleosome dynamics
transcription
DNA replication
Online Access:https://elifesciences.org/articles/40988

Internet

https://elifesciences.org/articles/40988

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