Targeting of AKT/ERK/CTNNB1 by DAW22 as a potential therapeutic compound for malignant peripheral nerve sheath tumor

Targeting of AKT/ERK/CTNNB1 by DAW22 as a potential therapeutic compound for malignant peripheral nerve sheath tumor

Abstract Malignant peripheral nerve sheath tumors (MPNSTs) are an aggressive form of soft tissue neoplasm with extremely poor prognosis and no effective medical options currently available. MPNSTs can occur either sporadically or in association with the neurofibromatosis type 1 (NF1) syndrome. Impor...

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Bibliographic Details
Main Authors: Xiao‐Xiao Li, Shi‐Jie Zhang, Amy P. Chiu, Lilian H. Lo, Jian Huang, Dewi K. Rowlands, Jinhui Wang, Vincent W. Keng
Format: Article
Language:English
Published: Wiley 2018-09-01
Series:Cancer Medicine
Subjects:
AKT
apoptosis
DAW22
ERK
MPNST
Online Access:https://doi.org/10.1002/cam4.1732

Internet

https://doi.org/10.1002/cam4.1732

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