New approaches to the synthesis of diclofenac choline

The process described herein proceeds to obtaining diclofenac choline from choline bicarbonate and diclofenac acid in mild conditions, using non-toxic solvent, with the same impurity profile deriving from diclofenac particle as for diclofenac sodium EP. The substance is also substantially free from...

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Main Authors:	Elżbieta Dąbrowska-Maś, Wojciech Raś
Format:	Article
Language:	English
Published:	Growing Science 2017-07-01
Series:	Current Chemistry Letters
Subjects:	Diclofenac choline Anti-inflammatory agent Oromucosal solution Mouthwash solution
Online Access:	http://www.growingscience.com/ccl/Vol6/ccl_2017_11.pdf

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spelling	doaj-0da5a497abea4860bb9b7d37c6fa44302020-11-24T23:18:29ZengGrowing ScienceCurrent Chemistry Letters1927-72961927-730X2017-07-016415916610.5267/j.ccl.2017.6.003New approaches to the synthesis of diclofenac cholineElżbieta Dąbrowska-MaśWojciech Raś The process described herein proceeds to obtaining diclofenac choline from choline bicarbonate and diclofenac acid in mild conditions, using non-toxic solvent, with the same impurity profile deriving from diclofenac particle as for diclofenac sodium EP. The substance is also substantially free from impurities deriving from choline and free from inorganic by-products, what means that the quality may be accepted for use as an active substance in medicine.http://www.growingscience.com/ccl/Vol6/ccl_2017_11.pdfDiclofenac cholineAnti-inflammatory agentOromucosal solutionMouthwash solution
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Elżbieta Dąbrowska-Maś Wojciech Raś
spellingShingle	Elżbieta Dąbrowska-Maś Wojciech Raś New approaches to the synthesis of diclofenac choline Current Chemistry Letters Diclofenac choline Anti-inflammatory agent Oromucosal solution Mouthwash solution
author_facet	Elżbieta Dąbrowska-Maś Wojciech Raś
author_sort	Elżbieta Dąbrowska-Maś
title	New approaches to the synthesis of diclofenac choline
title_short	New approaches to the synthesis of diclofenac choline
title_full	New approaches to the synthesis of diclofenac choline
title_fullStr	New approaches to the synthesis of diclofenac choline
title_full_unstemmed	New approaches to the synthesis of diclofenac choline
title_sort	new approaches to the synthesis of diclofenac choline
publisher	Growing Science
series	Current Chemistry Letters
issn	1927-7296 1927-730X
publishDate	2017-07-01
description	The process described herein proceeds to obtaining diclofenac choline from choline bicarbonate and diclofenac acid in mild conditions, using non-toxic solvent, with the same impurity profile deriving from diclofenac particle as for diclofenac sodium EP. The substance is also substantially free from impurities deriving from choline and free from inorganic by-products, what means that the quality may be accepted for use as an active substance in medicine.
topic	Diclofenac choline Anti-inflammatory agent Oromucosal solution Mouthwash solution
url	http://www.growingscience.com/ccl/Vol6/ccl_2017_11.pdf
work_keys_str_mv	AT elzbietadabrowskamas newapproachestothesynthesisofdiclofenaccholine AT wojciechras newapproachestothesynthesisofdiclofenaccholine
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New approaches to the synthesis of diclofenac choline

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