Dual Role of ROS as Signal and Stress Agents: Iron Tips the Balance in favor of Toxic Effects

Iron is essential for life, while also being potentially harmful. Therefore, its level is strictly monitored and complex pathways have evolved to keep iron safely bound to transport or storage proteins, thereby maintaining homeostasis at the cellular and systemic levels. These sequestration mechanis...

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Bibliographic Details
Main Authors: Elena Gammella, Stefania Recalcati, Gaetano Cairo
Format: Article
Language:English
Published: Hindawi Limited 2016-01-01
Series:Oxidative Medicine and Cellular Longevity
Online Access:http://dx.doi.org/10.1155/2016/8629024