C13 Megastigmane Derivatives From Epipremnum pinnatum: β-Damascenone Inhibits the Expression of Pro-Inflammatory Cytokines and Leukocyte Adhesion Molecules as Well as NF-κB Signaling

C13 Megastigmane Derivatives From Epipremnum pinnatum: β-Damascenone Inhibits the Expression of Pro-Inflammatory Cytokines and Leukocyte Adhesion Molecules as Well as NF-κB Signaling

In order to identify active constituents and to gain some information regarding their mode of action, extracts from leaves of Epipremnum pinnatum were tested for their ability to inhibit inflammatory gene expression in endothelial- and monocyte-like cells (HUVECtert and THP-1, respectively). Bioacti...

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Bibliographic Details
Main Authors: San-Po Pan, Teresa Pirker, Olaf Kunert, Nadine Kretschmer, Scarlet Hummelbrunner, Simone L. Latkolik, Julia Rappai, Verena M. Dirsch, Valery Bochkov, Rudolf Bauer
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-11-01
Series:Frontiers in Pharmacology
Subjects:
β-damascenone
megastigmane
Epipremnum pinnatum
COX-2
IL-8
NF-κB
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2019.01351/full

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https://www.frontiersin.org/article/10.3389/fphar.2019.01351/full

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