Targeting the Wnt signaling pathway through R-spondin 3 identifies an anti-fibrosis treatment strategy for multiple organs.

Targeting the Wnt signaling pathway through R-spondin 3 identifies an anti-fibrosis treatment strategy for multiple organs.

The Wnt/β-catenin signaling pathway has been implicated in human proliferative diseases such as cancer and fibrosis. The functions of β-catenin and several other components of this pathway have been investigated in fibrosis. However, the potential role of R-spondin proteins (RSPOs), enhancers of the...

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Bibliographic Details
Main Authors: Mingjun Zhang, Michael Haughey, Nai-Yu Wang, Kate Blease, Ann M Kapoun, Suzana Couto, Igor Belka, Timothy Hoey, Matthew Groza, James Hartke, Brydon Bennett, Jennifer Cain, Austin Gurney, Brent Benish, Paola Castiglioni, Clifton Drew, Jean Lachowicz, Leon Carayannopoulos, Steven D Nathan, Jorg Distler, David A Brenner, Kandasamy Hariharan, Ho Cho, Weilin Xie
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2020-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0229445

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https://doi.org/10.1371/journal.pone.0229445

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