Nfatc4 Deficiency Attenuates Ototoxicity by Suppressing Tnf-Mediated Hair Cell Apoptosis in the Mouse Cochlea

Nfatc4 Deficiency Attenuates Ototoxicity by Suppressing Tnf-Mediated Hair Cell Apoptosis in the Mouse Cochlea

The loss of sensory hair cells in the cochlea is the major cause of sensorineural hearing loss, and inflammatory processes and immune factors in response to cochlear damage have been shown to induce hair cell apoptosis. The expression and function of Nfatc4 in the cochlea remains unclear. In this st...

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Bibliographic Details
Main Authors: Yanping Zhang, Diyan Chen, Liping Zhao, Wen Li, Yusu Ni, Yan Chen, Huawei Li
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-07-01
Series:Frontiers in Immunology
Subjects:
Nfatc4
inflammation
inner ear
cochlear hair cells
cell apoptosis
hearing loss
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.01660/full

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https://www.frontiersin.org/article/10.3389/fimmu.2019.01660/full

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