Decreased Density of Perineuronal Net in Prelimbic Cortex Is Linked to Depressive-Like Behavior in Young-Aged Rats

Decreased Density of Perineuronal Net in Prelimbic Cortex Is Linked to Depressive-Like Behavior in Young-Aged Rats

Perineuronal nets (PNNs) are condensed extracellular matrix (ECM) structures regulating developmental plasticity and protecting neurons against oxidative stress. PNN abnormalities have been observed in various psychiatric disorders such as schizophrenia and bipolar disorder, but the relationship bet...

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Bibliographic Details
Main Authors: Zhoulong Yu, Na Chen, Die Hu, Wenxi Chen, Yi Yuan, Shiqiu Meng, Wen Zhang, Lin Lu, Ying Han, Jie Shi
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-01-01
Series:Frontiers in Molecular Neuroscience
Subjects:
perineuronal nets
depression
CUMS
prelimbic cortex
neurocan
aggrecan
Online Access:https://www.frontiersin.org/article/10.3389/fnmol.2020.00004/full

Internet

https://www.frontiersin.org/article/10.3389/fnmol.2020.00004/full

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