In vitro screening of reversible and time-dependent inhibition on CYP3A by TM208 and TM209 in rat liver microsomes

In vitro screening of reversible and time-dependent inhibition on CYP3A by TM208 and TM209 in rat liver microsomes

TM208 and TM209, dithiocarbamate derivatives with potential anti-cancer effects, were evaluated in reversible and time-dependent cytochrome P450 (CYP) 3A inhibition assays in rat liver microsomes using testosterone as probe substrate. Both compounds were found to be weak reversible inhibitors and mo...

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Bibliographic Details
Main Authors: Miaoran Ning, Liang Li, Jian Li, Zaiquan Li, Runtao Li, Tianyan Zhou, Wei Lu
Format: Article
Language:English
Published: Elsevier 2012-04-01
Series:Acta Pharmaceutica Sinica B
Subjects:
TM208
TM209
RLMs
CYP3A
Reversible inhibition
TDI
DDI
Online Access:http://www.sciencedirect.com/science/article/pii/S2211383512000238

Internet

http://www.sciencedirect.com/science/article/pii/S2211383512000238

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