Human mesenchymal stem cell-derived extracellular vesicles/estrogen combined therapy safely ameliorates experimentally induced intrauterine adhesions in a female rat model

Human mesenchymal stem cell-derived extracellular vesicles/estrogen combined therapy safely ameliorates experimentally induced intrauterine adhesions in a female rat model

Abstract Background Mesenchymal stem cells (MSCs) have diverse functions in regulating injury and inflammation through the secretion of extracellular vesicles (EVs). Methods In this study, we investigated the systemic administration of extracellular vesicles derived from human umbilical cord mesench...

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Bibliographic Details
Main Authors: Nesrine Ebrahim, Ola Mostafa, Rania Ebrahim El Dosoky, Inas A. Ahmed, Ahmed S. Saad, Abeer Mostafa, Dina Sabry, Khalid Abdelaziz Ibrahim, Ayman Samir Farid
Format: Article
Language:English
Published: BMC 2018-06-01
Series:Stem Cell Research & Therapy
Subjects:
Intrauterine adhesions
UCMSCs-EVs
Estrogen
TNF-α
TGF-β
IL-1
Online Access:http://link.springer.com/article/10.1186/s13287-018-0924-z

Internet

http://link.springer.com/article/10.1186/s13287-018-0924-z

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