Development of a BiTE®-mediated CD8+ cytotoxic T-lymphocyte activity assay to assess immunomodulatory potential of drug candidates in Cynomolgus macaque

Development of a BiTE®-mediated CD8+ cytotoxic T-lymphocyte activity assay to assess immunomodulatory potential of drug candidates in Cynomolgus macaque

The immunotoxic potential of drug candidates is assessed through the examination of results from a variety of studies and endpoints. While the functional assessment of CD8+ cytotoxic T-lymphocytes (CTL) is well-characterized in the clinic, the lack of a robust macaque CTL functional assay has been a...

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Bibliographic Details
Main Authors: Brendon Frank, Yu-Ling Wei, Kyung-Hoon Kim, Abraham Guerrero, Hervé Lebrec, Mercedesz Balazs, Xiaoting Wang
Format: Article
Language:English
Published: Taylor & Francis Group 2018-01-01
Series:Journal of Immunotoxicology
Subjects:
Cynomolgus macaque
CTL
immunotoxicity
CD107a
IFNγ
Online Access:http://dx.doi.org/10.1080/1547691X.2018.1486342

Internet

http://dx.doi.org/10.1080/1547691X.2018.1486342

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