Genomic regression analysis of coordinated expression

Somatic copy number alterations (SCNA) can confound gene co-expression analysis in cancers. Here the authors develop a method to remove the effects of SCNA in co-expression analysis, improving the analysis of network rewiring in cancer, and provide a database with adjusted data from TCGA.

Bibliographic Details
Main Authors: Ling Cai, Qiwei Li, Yi Du, Jonghyun Yun, Yang Xie, Ralph J. DeBerardinis, Guanghua Xiao
Format: Article
Language:English
Published: Nature Publishing Group 2017-12-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-017-02181-0