The K+ channel opener 1-EBIO potentiates residual function of mutant CFTR in rectal biopsies from cystic fibrosis patients.

The K+ channel opener 1-EBIO potentiates residual function of mutant CFTR in rectal biopsies from cystic fibrosis patients.

BACKGROUND: The identification of strategies to improve mutant CFTR function remains a key priority in the development of new treatments for cystic fibrosis (CF). Previous studies demonstrated that the K⁺ channel opener 1-ethyl-2-benzimidazolone (1-EBIO) potentiates CFTR-mediated Cl⁻ secretion in cu...

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Bibliographic Details
Main Authors: Eva K Roth, Stephanie Hirtz, Julia Duerr, Daniel Wenning, Irmgard Eichler, Hans H Seydewitz, Margarida D Amaral, Marcus A Mall
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3164200?pdf=render

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http://europepmc.org/articles/PMC3164200?pdf=render

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