MRIP Regulates the Myosin IIA Activity and DDR1 Function to Enable Collagen Tractional Remodeling

MRIP Regulates the Myosin IIA Activity and DDR1 Function to Enable Collagen Tractional Remodeling

DDR1 is a collagen adhesion-mechanoreceptor expressed in fibrotic lesions. DDR1 mediates non-muscle myosin IIA (NMIIA)-dependent collagen remodeling. We discovered that the myosin phosphatase Rho-interacting protein (MRIP), is enriched in DDR1-NMIIA adhesions on collagen. MRIP regulates RhoA- and my...

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Bibliographic Details
Main Authors: Nuno M. Coelho, Andrew Wang, Petar Petrovic, Yongqiang Wang, Wilson Lee, Christopher A. McCulloch
Format: Article
Language:English
Published: MDPI AG 2020-07-01
Series:Cells
Subjects:
MRIP
DDR1
non-muscle myosin IIA
collagen remodeling
Online Access:https://www.mdpi.com/2073-4409/9/7/1672

Internet

https://www.mdpi.com/2073-4409/9/7/1672

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