Advances in the understanding of mitochondrial DNA as a pathogenic factor in inflammatory diseases [version 1; referees: 3 approved]

Advances in the understanding of mitochondrial DNA as a pathogenic factor in inflammatory diseases [version 1; referees: 3 approved]

Mitochondrial DNA (mtDNA) has many similarities with bacterial DNA because of their shared common ancestry. Increasing evidence demonstrates mtDNA to be a potent danger signal that is recognised by the innate immune system and can directly modulate the inflammatory response. In humans, elevated circ...

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Bibliographic Details
Main Authors: Ray K. Boyapati, Arina Tamborska, David A. Dorward, Gwo-Tzer Ho
Format: Article
Language:English
Published: F1000 Research Ltd 2017-02-01
Series:F1000Research
Subjects:
Acute Cardiovascular Problems
Acute Renal Failure
Autoimmunity
Bleeding & Coagulation Disorders
Cell Signaling
Cellular Death & Stress Responses
Cellular Microbiology & Pathogenesis
Clinical Immunology
Coronary Artery Disease
Diabetes & Obesity
Emergency Medicine
Etiology, Pathogenesis & Animal Models of Rheumatic Disease
Genetics of the Immune System
Heart Failure
Immune & Inflammatory Rheumatic Diseases (incl. Arthritis)
Immune Response
Immunity to Infections
Immunopharmacology & Hematologic Pharmacology
Innate Immunity
Leukocyte Signaling & Gene Expression
Liver Biology & Pathobiology
Medical Microbiology
Membranes & Sorting
Neurobiology of Disease & Regeneration
Nuclear Structure & Function
Pediatric Problems in Critical Care
Sepsis & Multiple Organ Failure in Critical Care
Virology
Online Access:https://f1000research.com/articles/6-169/v1

Internet

https://f1000research.com/articles/6-169/v1

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