Markers of MEK inhibitor resistance in low-grade serous ovarian cancer: EGFR is a potential therapeutic target

Markers of MEK inhibitor resistance in low-grade serous ovarian cancer: EGFR is a potential therapeutic target

Abstract Background Although low-grade serous ovarian cancer (LGSC) is rare, case-fatality rates are high as most patients present with advanced disease and current cytotoxic therapies are not overly effective. Recognizing that these cancers may be driven by MAPK pathway activation, MEK inhibitors (...

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Bibliographic Details
Main Authors: Marta Llaurado Fernandez, Amy Dawson, Joshua Hoenisch, Hannah Kim, Sylvia Bamford, Clara Salamanca, Gabriel DiMattia, Trevor Shepherd, Mattia Cremona, Bryan Hennessy, Shawn Anderson, Stanislav Volik, Colin C. Collins, David G. Huntsman, Mark S. Carey
Format: Article
Language:English
Published: BMC 2019-01-01
Series:Cancer Cell International
Subjects:
Ovarian cancer
MEK inhibitor
EGFR inhibitor
PKC-alpha
Predictive biomarkers
Online Access:http://link.springer.com/article/10.1186/s12935-019-0725-1

Internet

http://link.springer.com/article/10.1186/s12935-019-0725-1

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