Structural basis for the clamping and Ca2+ activation of SNARE-mediated fusion by synaptotagmin
The neuronal Ca2+-sensor Synapotagmin-1 (Syt1) interacts with SNARE proteins and lipid membranes and synchronizes neurotransmitter release in response to Ca2+-influx. Here the authors provide insights into the underlying molecular mechanism by determining the cryo-EM structure of the Syt1–SNARE comp...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Publishing Group
2019-06-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-019-10391-x |