Neferine Attenuates Acute Kidney Injury by Inhibiting NF-κB Signaling and Upregulating Klotho Expression

Neferine Attenuates Acute Kidney Injury by Inhibiting NF-κB Signaling and Upregulating Klotho Expression

Purpose: Morbidity associated with and mortality from acute kidney injury (AKI) is gradually increasing, and no efficient drug is available. We explored whether neferine, a bisbenzylisoquinoline alkaloid, attenuated AKI, and the possible mechanisms in play in vivo and in vitro.Methods: We induced AK...

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Bibliographic Details
Main Authors: Huihui Li, Wenhang Chen, Yusa Chen, Qiaoling Zhou, Ping Xiao, Rong Tang, Jing Xue
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-10-01
Series:Frontiers in Pharmacology
Subjects:
acute kidney injury (AKI)
neferine
NF-κB
Klotho
apoptosis
inflammation
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2019.01197/full

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https://www.frontiersin.org/article/10.3389/fphar.2019.01197/full

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