Synergistic effects of concurrent blockade of PI3K and MEK pathways in pancreatic cancer preclinical models.

Synergistic effects of concurrent blockade of PI3K and MEK pathways in pancreatic cancer preclinical models.

Patients with pancreatic cancer have dismal prognoses, and novel therapies are urgently needed. Mutations of the KRAS oncogene occur frequently in pancreatic cancer and represent an attractive target. Direct targeting of the predominant KRAS pathways have been challenging and research into therapeut...

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Bibliographic Details
Main Authors: Hua Zhong, Cesar Sanchez, Dirk Spitzer, Stacy Plambeck-Suess, Jesse Gibbs, Williams G Hawkins, David Denardo, Feng Gao, Robert A Pufahl, Albert C Lockhart, Mai Xu, David Linehan, Jason Weber, Andrea Wang-Gillam
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24130864/?tool=EBI

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24130864/?tool=EBI

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