Rapid In-Process Monitoring of Lentiviral Vector Particles by High-Performance Liquid Chromatography

Rapid In-Process Monitoring of Lentiviral Vector Particles by High-Performance Liquid Chromatography

Lentiviral vectors (LVs) are a popular gene delivery tool in cell and gene therapy and they are a primary tool for ex vivo transduction of T cells for expression of chimeric antigen receptor (CAR) in CAR-T cell therapies. Extensive process and product characterization are required in manufacturing v...

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Bibliographic Details
Main Authors: Julia Transfiguracion, Michelle Yen Tran, Stéphane Lanthier, Sonia Tremblay, Nathalie Coulombe, Mauro Acchione, Amine A. Kamen
Format: Article
Language:English
Published: Elsevier 2020-09-01
Series:Molecular Therapy: Methods & Clinical Development
Subjects:
high-performance liquid chromatography
lentiviral vector
particle quantification
Process Analytical Technologies
ratio transducing units to total particles
Online Access:http://www.sciencedirect.com/science/article/pii/S2329050120301716

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http://www.sciencedirect.com/science/article/pii/S2329050120301716

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