Separase loss of function cooperates with the loss of p53 in the initiation and progression of T- and B-cell lymphoma, leukemia and aneuploidy in mice.

Separase loss of function cooperates with the loss of p53 in the initiation and progression of T- and B-cell lymphoma, leukemia and aneuploidy in mice.

Cohesin protease Separase plays a key role in faithful segregation of sister chromatids by cleaving the cohesin complex at the metaphase to anaphase transition. Homozygous deletion of ESPL1 gene that encodes Separase protein results in embryonic lethality in mice and Separase overexpression lead to...

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Bibliographic Details
Main Authors: Malini Mukherjee, Gouqing Ge, Nenggang Zhang, Eryong Huang, Lanelle V Nakamura, Marissa Minor, Viacheslav Fofanov, Pullivarthi H Rao, Alan Herron, Debananda Pati
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3143119?pdf=render

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http://europepmc.org/articles/PMC3143119?pdf=render

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