Molecular subtyping reveals immune alterations associated with progression of bronchial premalignant lesions

Molecular subtyping reveals immune alterations associated with progression of bronchial premalignant lesions

Bronchial premalignant lesions can potentially progress to lung squamous cell carcinoma. Here, the authors profile bronchial biopsies from high-risk smokers by RNA sequencing and identify four molecular subtypes of premalignant lesions and an immune molecular signature that associates with lesion pr...

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Bibliographic Details
Main Authors: Jennifer E. Beane, Sarah A. Mazzilli, Joshua D. Campbell, Grant Duclos, Kostyantyn Krysan, Christopher Moy, Catalina Perdomo, Michael Schaffer, Gang Liu, Sherry Zhang, Hanqiao Liu, Jessica Vick, Samjot S. Dhillon, Suso J. Platero, Steven M. Dubinett, Christopher Stevenson, Mary E. Reid, Marc E. Lenburg, Avrum E. Spira
Format: Article
Language:English
Published: Nature Publishing Group 2019-04-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-019-09834-2

Internet

https://doi.org/10.1038/s41467-019-09834-2

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