Blockade of Endothelin-1 Receptor Type B Ameliorates Glucose Intolerance and Insulin Resistance in a Mouse Model of Obstructive Sleep Apnea

Blockade of Endothelin-1 Receptor Type B Ameliorates Glucose Intolerance and Insulin Resistance in a Mouse Model of Obstructive Sleep Apnea

Obstructive sleep apnea (OSA) is associated with insulin resistance (IR) and glucose intolerance. Elevated endothelin-1 (ET-1) levels have been observed in OSA patients and in mice exposed to intermittent hypoxia (IH). We examined whether pharmacological blockade of type A and type B ET-1 receptors...

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Bibliographic Details
Main Authors: Jan Polak, Naresh M. Punjabi, Larissa A. Shimoda
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-05-01
Series:Frontiers in Endocrinology
Subjects:
obstructive sleep apnea
endothelin
endothelin receptor
bosentan
diabetes
Online Access:https://www.frontiersin.org/article/10.3389/fendo.2018.00280/full

Internet

https://www.frontiersin.org/article/10.3389/fendo.2018.00280/full

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