Synthetic Lethal Activity of Benzophenanthridine Alkaloids From Zanthoxylum coco Against BRCA1-Deficient Cancer Cells

Synthetic Lethal Activity of Benzophenanthridine Alkaloids From Zanthoxylum coco Against BRCA1-Deficient Cancer Cells

Several plants from South America show strong antitumoral properties based on anti-proliferative and/or pro-apoptotic activities. In this work we aimed to identify selective cytotoxic compounds that target BRCA1-deficient cancer cells by Synthetic Lethality (SL) induction. Using a high-throughput sc...

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Bibliographic Details
Main Authors: Iris A. García, Maria Florencia Pansa, Adriana Del Valle Pacciaroni, Manuela E. García, Maria Laura Gonzalez, Juan Carlos Oberti, José Luís Bocco, Maria Cecilia Carpinella, Gloria E. Barboza, Viviana E. Nicotra, Gastón Soria
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-12-01
Series:Frontiers in Pharmacology
Subjects:
natural products
Zanthoxylum coco
oxynitidine
nitidine
drug discovery
BRCA1
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2020.593845/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2020.593845/full

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