Effects of apolipoprotein E isoform, sex, and diet on insulin BBB pharmacokinetics in mice

Abstract Age, apolipoprotein E (apoE) isoform, sex, and diet can independently affect the risk for the development of Alzheimer’s disease (AD). Additionally, synergy between some of these risk factors have been observed. However, the relation between the latter three risk factors has not been invest...

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Bibliographic Details
Main Authors: Elizabeth M. Rhea, Kim Hansen, Sarah Pemberton, Eileen Ruth S. Torres, Sarah Holden, Jacob Raber, William A. Banks
Format: Article
Language:English
Published: Nature Publishing Group 2021-09-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-021-98061-1