Degradation of AMPK‐α1 sensitizes BRAF inhibitor‐resistant melanoma cells to arginine deprivation

Degradation of AMPK‐α1 sensitizes BRAF inhibitor‐resistant melanoma cells to arginine deprivation

Melanomas harboring BRAF mutation (V600E) are known to recur frequently following treatment with BRAF inhibitors (BRAFi) despite a high initial response rate. Our previous study has uncovered that BRAFi‐resistant melanoma (BR) cells are vulnerable to arginine deprivation. It has been reported that n...

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Bibliographic Details
Main Authors: Ying‐Ying Li, Chunjing Wu, Sumedh S. Shah, Shu‐Mei Chen, Medhi Wangpaichitr, Macus T. Kuo, Lynn G. Feun, Xiaoqing Han, Miguel Suarez, Jeffrey Prince, Niramol Savaraj
Format: Article
Language:English
Published: Wiley 2017-12-01
Series:Molecular Oncology
Subjects:
AMPK‐α1
autophagy
BRAF inhibitor‐resistant melanoma
E3 ubiquitin ligase
metabolic reprogramming
ubiquitin‐proteasome system
Online Access:https://doi.org/10.1002/1878-0261.12151

Internet

https://doi.org/10.1002/1878-0261.12151

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