Synthesis and Antitumor Activity of Amino Acid Ester Derivatives Containing 5-Fluorouracil

Synthesis and Antitumor Activity of Amino Acid Ester Derivatives Containing 5-Fluorouracil

A series of amino acid ester derivatives containing 5-fluorouracil were synthesized using 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride (EDC•HCl) and N-hydroxybenzotriazole (HOBt) as a coupling agent. The structures of the products were assigned by NMR, MS, IR etc. The in vitro antitum...

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Bibliographic Details
Main Authors: Jing Xiong, Hai-Feng Zhu, Ya-Juan Zhao, Yun-Jun Lan, Ji-Wang Jiang, Jing-Jing Yang, Shu-Feng Zhang
Format: Article
Language:English
Published: MDPI AG 2009-08-01
Series:Molecules
Subjects:
5-fluorouracil
amino acid ester
antitumor activity
Online Access:http://www.mdpi.com/1420-3049/14/9/3142/

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http://www.mdpi.com/1420-3049/14/9/3142/

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