Protein kinase A antagonist inhibits β-catenin nuclear translocation, c-Myc and COX-2 expression and tumor promotion in <it>Apc</it><sup>Min/+ </sup>mice

Protein kinase A antagonist inhibits β-catenin nuclear translocation, c-Myc and COX-2 expression and tumor promotion in <it>Apc</it><sup>Min/+ </sup>mice

<p>Abstract</p> <p>Background</p> <p>The adenomatous polyposis coli (APC) protein is part of the destruction complex controlling proteosomal degradation of β-catenin and limiting its nuclear translocation, which is thought to play a gate-keeping role in colorectal cance...

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Bibliographic Details
Main Authors: Brudvik Kristoffer W, Paulsen Jan E, Aandahl Einar M, Roald Borghild, Taskén Kjetil
Format: Article
Language:English
Published: BMC 2011-12-01
Series:Molecular Cancer
Subjects:
<it>Apc</it><sup>Min/+</sup>/b-catenin
Colorectal cancer
COX-2
protein kinase A
Online Access:http://www.molecular-cancer.com/content/10/1/149

Internet

http://www.molecular-cancer.com/content/10/1/149

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