Impaired Insulin Signaling is Associated with Hepatic Mitochondrial Dysfunction in IR+/−-IRS-1+/− Double Heterozygous (IR-IRS1dh) Mice

Impaired Insulin Signaling is Associated with Hepatic Mitochondrial Dysfunction in IR+/−-IRS-1+/− Double Heterozygous (IR-IRS1dh) Mice

Mitochondria play a pivotal role in energy metabolism, but whether insulin signaling per se could regulate mitochondrial function has not been identified yet. To investigate whether mitochondrial function is regulated by insulin signaling, we analyzed muscle and liver of insulin receptor (IR)+/−-ins...

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Bibliographic Details
Main Authors: Andras Franko, Alexander Kunze, Marlen Böse, Jürgen-Christoph von Kleist-Retzow, Mats Paulsson, Ursula Hartmann, Rudolf J. Wiesner
Format: Article
Language:English
Published: MDPI AG 2017-05-01
Series:International Journal of Molecular Sciences
Subjects:
insulin signaling
insulin receptor
insulin receptor substrate 1
mitochondria
liver
skeletal muscle
glucose metabolism
Online Access:http://www.mdpi.com/1422-0067/18/6/1156

Internet

http://www.mdpi.com/1422-0067/18/6/1156

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