Protective effects of silymarin on methotrexate-induced damages in rat testes

Abstract The present study aimed to investigate the protective effects of silymarin (SMN), an antioxidant, on methotrexate (MTX)-induced damage in rat testes. Thirty-two Wistar albino rats were divided into four groups (n = 8): control, MTX (20 mg/kg, i.p. on days 1 and 5), SMN (200 mg/kg, orally),...

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Bibliographic Details
Main Authors: Turan Yaman, Ahmet Uyar, Mehmet Salih Kaya, Ömer Faruk Keles, Baris Atalay Uslu, Zabit Yener
Format: Article
Language:English
Published: Universidade de São Paulo 2018-06-01
Series:Brazilian Journal of Pharmaceutical Sciences
Subjects:
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502018000100618&lng=en&tlng=en