Grape seed flavanols decrease blood pressure via Sirt-1 and confer a vasoprotective pattern in rats

Involvement of nitric oxide (NO) in the antihypertensive effect of grape seed flavanols was previously demonstrated. This study investigates the endothelial vasoprotective pattern and the role of Sirtuin-1 (Sirt-1) in this antihypertensive effect. Cafeteria diet-fed hypertensive rats (CHR) were admi...

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Bibliographic Details
Main Authors: Z. Pons, M. Margalef, F.I. Bravo, A. Arola-Arnal, B. Muguerza
Format: Article
Language:English
Published: Elsevier 2016-06-01
Series:Journal of Functional Foods
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S1756464616300512