Association of Cigarette Smoking, COPD, and Lung Cancer With Expression of SARS-CoV-2 Entry Genes in Human Airway Epithelial Cells

Association of Cigarette Smoking, COPD, and Lung Cancer With Expression of SARS-CoV-2 Entry Genes in Human Airway Epithelial Cells

SARS-CoV-2 enters into human airway epithelial cells via membrane fusion or endocytosis, and this process is dependent on ACE2, TMPRSS2, and cathepsin L. In this study, we examined the expression profiles of the three SARS-CoV-2 entry genes in primary human airway epithelial cells isolated from smok...

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Bibliographic Details
Main Authors: Junping Yin, Brigitte Kasper, Frank Petersen, Xinhua Yu
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-12-01
Series:Frontiers in Medicine
Subjects:
COVID-19
SARS-CoV-2
human airway epithelial cells
ACE2 (angiotensin converting enzyme-2)
smoking
transmembrane serine protease 2
Online Access:https://www.frontiersin.org/articles/10.3389/fmed.2020.619453/full

Internet

https://www.frontiersin.org/articles/10.3389/fmed.2020.619453/full

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