Synthesis and evaluation of chloramphenicol homodimers: molecular target, antimicrobial activity, and toxicity against human cells.

As fight against antibiotic resistance must be strengthened, improving old drugs that have fallen in reduced clinical use because of toxic side effects and/or frequently reported resistance, like chloramphenicol (CAM), is of special interest. Chloramphenicol (CAM), a prototypical wide-spectrum antib...

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Bibliographic Details
Main Authors: Ourania N Kostopoulou, George E Magoulas, Georgios E Papadopoulos, Athanasia Mouzaki, George P Dinos, Dionissios Papaioannou, Dimitrios L Kalpaxis
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4533973?pdf=render