Increase in Toxicity of Anticancer Drugs by PMTPV, a Claudin-1-Binding Peptide, Mediated via Down-Regulation of Claudin-1 in Human Lung Adenocarcinoma A549 Cells

Increase in Toxicity of Anticancer Drugs by PMTPV, a Claudin-1-Binding Peptide, Mediated via Down-Regulation of Claudin-1 in Human Lung Adenocarcinoma A549 Cells

Claudin-1 (CLDN1), a tight junctional protein, is highly expressed in lung cancer cells and may contribute to chemoresistance. A drug which decreases CLDN1 expression could be a chemosensitizer for enhancing the efficacy of anticancer drugs, but there is no such drug known. We found that PMTPV, a sh...

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Bibliographic Details
Main Authors: Haruka Nasako, Yui Takashina, Hiroaki Eguchi, Ayaka Ito, Yoshinobu Ishikawa, Toshiyuki Matsunaga, Satoshi Endo, Akira Ikari
Format: Article
Language:English
Published: MDPI AG 2020-08-01
Series:International Journal of Molecular Sciences
Subjects:
claudin-1
lung adenocarcinoma
chemoresistance
short peptide
Online Access:https://www.mdpi.com/1422-0067/21/16/5909

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https://www.mdpi.com/1422-0067/21/16/5909

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