Role of Gag and lipids during HIV-1 assembly in CD4 T cells and Macrophages

Role of Gag and lipids during HIV-1 assembly in CD4 T cells and Macrophages

HIV-1 is an RNA enveloped virus that preferentiallyinfects CD4+ T lymphocytes andalso macrophages. In CD4+ T cells, HIV-1mainly buds from the host cell plasma membrane.The viral Gag polyprotein targets theplasma membrane and is the orchestrator ofthe HIV assembly as its expression is sufficientto pr...

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Bibliographic Details
Main Authors: Charlotte eMariani, Marion eDesdouits, Cyril eFavard, Philippe eBenaroch, Delphine M Muriaux
Format: Article
Language:English
Published: Frontiers Media S.A. 2014-06-01
Series:Frontiers in Microbiology
Subjects:
HIV-1
Lipids
Macrophages
Gag
Assembly
CD4 T-cells
Online Access:http://journal.frontiersin.org/Journal/10.3389/fmicb.2014.00312/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fmicb.2014.00312/full

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