Suppression of leaky expression of adenovirus genes by insertion of microRNA-targeted sequences in the replication-incompetent adenovirus vector genome

Suppression of leaky expression of adenovirus genes by insertion of microRNA-targeted sequences in the replication-incompetent adenovirus vector genome

Leaky expression of adenovirus (Ad) genes occurs following transduction with a conventional replication-incompetent Ad vector, leading to an induction of cellular immunity against Ad proteins and Ad protein-induced toxicity, especially in the late phase following administration. To suppress the leak...

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Bibliographic Details
Main Authors: Kahori Shimizu, Fuminori Sakurai, Kyoko Tomita, Yasuhito Nagamoto, Shin-ichiro Nakamura, Kazufumi Katayama, Masashi Tachibana, Kenji Kawabata, Hiroyuki Mizuguchi
Format: Article
Language:English
Published: Elsevier 2014-01-01
Series:Molecular Therapy: Methods & Clinical Development
Online Access:http://www.sciencedirect.com/science/article/pii/S2329050116301024

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http://www.sciencedirect.com/science/article/pii/S2329050116301024

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