Vaccination with EphA2-derived T cell-epitopes promotes immunity against both EphA2-expressing and EphA2-negative tumors

Vaccination with EphA2-derived T cell-epitopes promotes immunity against both EphA2-expressing and EphA2-negative tumors

<p>Abstract</p> <p>Background</p> <p>A novel tyrosine kinase receptor EphA2 is expressed at high levels in advanced and metastatic cancers. We examined whether vaccinations with synthetic mouse EphA2 (mEphA2)-derived peptides that serve as T cell epitopes could induce p...

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Bibliographic Details
Main Authors: Hatano Manabu, Kuwashima Naruo, Tatsumi Tomohide, Dusak Jill E, Nishimura Fumihiko, Reilly Karlyne M, Storkus Walter J, Okada Hideho
Format: Article
Language:English
Published: BMC 2004-11-01
Series:Journal of Translational Medicine
Subjects:
EphA2
dendritic cells
cancer vaccines
melanoma
Online Access:http://www.translational-medicine.com/content/2/1/40

Internet

http://www.translational-medicine.com/content/2/1/40

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