Retrovirally Transferred Genes Inhibit Apoptosis in an Insulin-Secreting Cell Line: Implications for Islet Transplantation

The transplantation of pancreatic islets for the treatment of type I diabetes is hindered by the enormous loss of cells due to early apoptotic events. Genetic engineering of islets with cytoprotective genes is an important strategy aimed to enhance the survival of these cells in the transplant setti...

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Bibliographic Details
Main Authors: Elizabeth S. Fenjves, M. Sofia Ochoa, Carlota Gay-Rabinstein, Camillo Ricordi, Michael A. Curran
Format: Article
Language:English
Published: SAGE Publishing 2004-07-01
Series:Cell Transplantation
Online Access:https://doi.org/10.3727/000000004783983710