Terminating contamination: large-scale search identifies more than 2,000,000 contaminated entries in GenBank

Abstract Genomic analyses are sensitive to contamination in public databases caused by incorrectly labeled reference sequences. Here, we describe Conterminator, an efficient method to detect and remove incorrectly labeled sequences by an exhaustive all-against-all sequence comparison. Our analysis r...

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Bibliographic Details
Main Authors: Martin Steinegger, Steven L. Salzberg
Format: Article
Language:English
Published: BMC 2020-05-01
Series:Genome Biology
Subjects:
Online Access:http://link.springer.com/article/10.1186/s13059-020-02023-1