Ketone ester supplementation attenuates seizure activity, and improves behavior and hippocampal synaptic plasticity in an Angelman syndrome mouse model

Ketone ester supplementation attenuates seizure activity, and improves behavior and hippocampal synaptic plasticity in an Angelman syndrome mouse model

Angelman syndrome (AS) is a rare genetic and neurological disorder presenting with seizures, developmental delay, ataxia, and lack of speech. Previous studies have indicated that oxidative stress-dependent metabolic dysfunction may underlie the phenotypic deficits reported in the AS mouse model. Whi...

Full description

Bibliographic Details
Main Authors: Stephanie L. Ciarlone, Joseph C. Grieco, Dominic P. D'Agostino, Edwin J. Weeber
Format: Article
Language:English
Published: Elsevier 2016-12-01
Series:Neurobiology of Disease
Subjects:
Angelman syndrome
Seizure
Ketone ester
Motor coordination
Metabolism
Synaptic plasticity
Online Access:http://www.sciencedirect.com/science/article/pii/S096999611630198X

Internet

http://www.sciencedirect.com/science/article/pii/S096999611630198X

Similar Items