PI(4)P Promotes Phosphorylation and Conformational Change of Smoothened through Interaction with Its C-terminal Tail.

PI(4)P Promotes Phosphorylation and Conformational Change of Smoothened through Interaction with Its C-terminal Tail.

In Hedgehog (Hh) signaling, binding of Hh to the Patched-Interference Hh (Ptc-Ihog) receptor complex relieves Ptc inhibition on Smoothened (Smo). A longstanding question is how Ptc inhibits Smo and how such inhibition is relieved by Hh stimulation. In this study, we found that Hh elevates production...

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Bibliographic Details
Main Authors: Kai Jiang, Yajuan Liu, Junkai Fan, Jie Zhang, Xiang-An Li, B Mark Evers, Haining Zhu, Jianhang Jia
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2016-02-01
Series:PLoS Biology
Online Access:http://europepmc.org/articles/PMC4749301?pdf=render

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http://europepmc.org/articles/PMC4749301?pdf=render

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