Implications of Metastable Nicks and Nicked Holliday Junctions in Processing Joint Molecules in Mitosis and Meiosis

Implications of Metastable Nicks and Nicked Holliday Junctions in Processing Joint Molecules in Mitosis and Meiosis

Joint molecules (JMs) are intermediates of homologous recombination (HR). JMs rejoin sister or homolog chromosomes and must be removed timely to allow segregation in anaphase. Current models pinpoint Holliday junctions (HJs) as a central JM. The canonical HJ (cHJ) is a four-way DNA that needs specia...

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Bibliographic Details
Main Author: Félix Machín
Format: Article
Language:English
Published: MDPI AG 2020-12-01
Series:Genes
Subjects:
holliday junction
homologous recombination
Mus81
GEN1/Yen1
BLM/Sgs1
Mlh1-Mlh3/MutLγ
Online Access:https://www.mdpi.com/2073-4425/11/12/1498

Internet

https://www.mdpi.com/2073-4425/11/12/1498

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