New Polymorphic Forms of Pemetrexed Diacid and Their Use for the Preparation of Pharmaceutically Pure Amorphous and Hemipentahydrate Forms of Pemetrexed Disodium

New Polymorphic Forms of Pemetrexed Diacid and Their Use for the Preparation of Pharmaceutically Pure Amorphous and Hemipentahydrate Forms of Pemetrexed Disodium

The preparation of stable amorphous pemetrexed disodium of pharmaceutical purity as well as the process optimization for the preparation of the hemipentahydrate form of pemetrexed disodium are described. Analytical methods for the polymorphic and chemical purity studies of pemetrexed disodium and pe...

Full description

Bibliographic Details
Main Authors: Olga Michalak, Marta Łaszcz, Kamil Jatczak, Anna Witkowska, Iwona Bujak, Aleksandra Groman, Marcin Cybulski
Format: Article
Language:English
Published: MDPI AG 2015-07-01
Series:Molecules
Subjects:
pemetrexed diacid
pemetrexed disodium
powder X-ray diffraction
thermal analysis
phase transition
Online Access:http://www.mdpi.com/1420-3049/20/8/13814

Internet

http://www.mdpi.com/1420-3049/20/8/13814

Similar Items