Conservation, variability and the modeling of active protein kinases.

The human proteome is rich with protein kinases, and this richness has made the kinase of crucial importance in initiating and maintaining cell behavior. Elucidating cell signaling networks and manipulating their components to understand and alter behavior require well designed inhibitors. These inh...

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Bibliographic Details
Main Authors: James D R Knight, Bin Qian, David Baker, Rashmi Kothary
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2007-10-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC1989141?pdf=render