Deregulation of Ca<sup>2+</sup>-Signaling Systems in White Adipocytes, Manifested as the Loss of Rhythmic Activity, Underlies the Development of Multiple Hormonal Resistance at Obesity and Type 2 Diabetes

Deregulation of Ca<sup>2+</sup>-Signaling Systems in White Adipocytes, Manifested as the Loss of Rhythmic Activity, Underlies the Development of Multiple Hormonal Resistance at Obesity and Type 2 Diabetes

Various types of cells demonstrate ubiquitous rhythmicity registered as simple and complex Ca<sup>2+</sup>-oscillations, spikes, waves, and triggering phenomena mediated by G-protein and tyrosine kinase coupled receptors. Phospholipase C/IP<sub>3</sub>-receptors (PLC/IP<su...

Full description

Bibliographic Details
Main Authors: Egor A. Turovsky, Maria V. Turovskaya, Vladimir V. Dynnik
Format: Article
Language:English
Published: MDPI AG 2021-05-01
Series:International Journal of Molecular Sciences
Subjects:
murine white adipocytes
G proteins interplay
feedback control of Ca<sup>2+</sup> signaling systems
Ca<sup>2+</sup> oscillations and triggering phenomena
NO and protein kinase G
loss of rhythmicity and general hormonal resistance to obesity
Online Access:https://www.mdpi.com/1422-0067/22/10/5109

Internet

https://www.mdpi.com/1422-0067/22/10/5109

Similar Items