Brucella Rough Mutant Induce Macrophage Death via Activating IRE1α Pathway of Endoplasmic Reticulum Stress by Enhanced T4SS Secretion

Brucella Rough Mutant Induce Macrophage Death via Activating IRE1α Pathway of Endoplasmic Reticulum Stress by Enhanced T4SS Secretion

Brucella is a Gram-negative facultative intracellular pathogen that causes the worldwide zoonosis, known as brucellosis. Brucella virulence relies mostly on its ability to invade and replicate within phagocytic cells. The type IV secretion system (T4SS) and lipopolysaccharide are two major Brucella...

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Bibliographic Details
Main Authors: Peng Li, Mingxing Tian, Yanqing Bao, Hai Hu, Jiameng Liu, Yi Yin, Chan Ding, Shaohui Wang, Shengqing Yu
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-09-01
Series:Frontiers in Cellular and Infection Microbiology
Subjects:
Brucella
Type IV secretion system
lipopolysaccharide
VjbR
endoplasmic reticulum stress
Online Access:http://journal.frontiersin.org/article/10.3389/fcimb.2017.00422/full

Internet

http://journal.frontiersin.org/article/10.3389/fcimb.2017.00422/full

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