The loss-of-function disease-mutation G301R in the Na+/K+-ATPase α2 isoform decreases lesion volume and improves functional outcome after acute spinal cord injury in mice

The loss-of-function disease-mutation G301R in the Na+/K+-ATPase α2 isoform decreases lesion volume and improves functional outcome after acute spinal cord injury in mice

Abstract Background The Na+/K+-ATPases are transmembrane ion pumps important for maintenance of ion gradients across the plasma membrane that serve to support multiple cellular functions, such as membrane potentials, regulation of cellular volume and pH, and co-transport of signaling transmitters in...

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Bibliographic Details
Main Authors: Ditte Gry Ellman, Toke Jost Isaksen, Minna Christiansen Lund, Safinaz Dursun, Martin Wirenfeldt, Louise Helskov Jørgensen, Karin Lykke-Hartmann, Kate Lykke Lambertsen
Format: Article
Language:English
Published: BMC 2017-09-01
Series:BMC Neuroscience
Subjects:
Spinal cord injury
Na+/K+-ATPase α2 isoform
Functional recovery
Reduced lesion volume
Online Access:http://link.springer.com/article/10.1186/s12868-017-0385-9

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http://link.springer.com/article/10.1186/s12868-017-0385-9

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